Last update
5/23/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Calcium (as Dibasic Calcium Phosphate)
32 mg
2%
5-HTP (5-Hydroxytryptophan)[from Griffonia simplicifolia) (seed)
100 mg
*
Top Medical Research Studies
7
In our investigation, we examined the impact of 5-hydroxytryptophan (5-HTP) on individuals with irritable bowel syndrome (IBS) compared to healthy volunteers.
Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.
Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.
Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.
Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.
Read More
4
We assessed the impact of 5-hydroxytryptophan (5-HTP) on intestinal health in patients with irritable bowel syndrome (IBS) and healthy individuals. In a randomised double-blind placebo-controlled study, we found that while 5-HTP improved mucosal serotonin levels and reinforced intestinal barriers in healthy participants, the same benefits were absent in IBS patients. This suggests IBS may involve a dysfunctional serotonin system, hindering the ability to strengthen the intestinal barrier even after 5-HTP treatment. Overall, our findings indicate limited effectiveness for 5-HTP in treating IBS.
Read More
Most Useful Reviews
7.5
Less irritability noted
3 people found this helpful
Notable improvements since I began taking a pill before bedtime. It's challenging to assess the results, but I clearly see positive effects, although some may be attributed to the placebo effect. In the morning, I crave less food and feel less irritable. Overeating has significantly reduced since I started this treatment for irritable bowel syndrome. There are no side effects, and the tablets are small and easy to swallow. I highly recommend them.
Read More
7.5
Calm and composed
3 people found this helpful
I have become much calmer and less irritable. What once triggered intense anger now brings only a smile. I've stopped overreacting to minor issues. Working in customer service, this treatment for irritable bowel syndrome has been invaluable, helping me maintain my composure and leave work with a smile instead of frustration.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
- All Researches
7
In our investigation, we examined the impact of 5-hydroxytryptophan (5-HTP) on individuals with irritable bowel syndrome (IBS) compared to healthy volunteers.
Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.
Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.
Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.
Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.
Read More
4
We assessed the impact of 5-hydroxytryptophan (5-HTP) on intestinal health in patients with irritable bowel syndrome (IBS) and healthy individuals. In a randomised double-blind placebo-controlled study, we found that while 5-HTP improved mucosal serotonin levels and reinforced intestinal barriers in healthy participants, the same benefits were absent in IBS patients. This suggests IBS may involve a dysfunctional serotonin system, hindering the ability to strengthen the intestinal barrier even after 5-HTP treatment. Overall, our findings indicate limited effectiveness for 5-HTP in treating IBS.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Less irritability noted
3 people found this helpful
Notable improvements since I began taking a pill before bedtime. It's challenging to assess the results, but I clearly see positive effects, although some may be attributed to the placebo effect. In the morning, I crave less food and feel less irritable. Overeating has significantly reduced since I started this treatment for irritable bowel syndrome. There are no side effects, and the tablets are small and easy to swallow. I highly recommend them.
Read More
7.5
Calm and composed
3 people found this helpful
I have become much calmer and less irritable. What once triggered intense anger now brings only a smile. I've stopped overreacting to minor issues. Working in customer service, this treatment for irritable bowel syndrome has been invaluable, helping me maintain my composure and leave work with a smile instead of frustration.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Keszthelyi D, Troost FJ, Jonkers DM, van Eijk HM, Dekker J, et al. Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study. Neurogastroenterol Motil. 2015;27:1127. 10.1111/nmo.12600
- Keszthelyi D, Troost FJ, Jonkers DM, van Eijk HM, Lindsey PJ, et al. Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome. Aliment Pharmacol Ther. 2014;40:392. 10.1111/apt.12842
